… These mouse blood islands, first described back to 1920 in … The clonal contribution of a
hemangioblast to a single blood … These early studies revealed that macrophages in various …

… lineage/clonal analyses, we show an unsuspected clonal relationship … by clonal analyses
in the mouse embryo, which revealed two … labeled clones in the heart and yolk sac at E9.5. E, …

… Clonal transplantation analyses revealed the heterogeneity … at mouse embryonic day (E)7.5
in the YS blood islands with … hemangioblastic chords containing polyclonal cells with …

… cell, single-structure analysis reveals a robust recapitulation of cell … From the four clones we
tested, we selected the clone with the … As we had observed blood islands on the yolk-sac-like …

… revealed that the first blood cells appear in the yolk sac (YS): … an endothelial layer, named
blood islands. The order of events … , mice, and humans) were the first where the distinct origins …

… studies despite the fact that mouse development is highly specialized … The origin of the yolk
sac blood islands is polyclonal [40], … Clonal analysis identifies hemogenic endothelium as the …

… hinted at the highly polyclonal nature of human adult blood and … in blood islands of the yolk
sac, and by E8.5 in mouse or 32 hpf … -tracing studies have revealed an HSC origin for specific …

… This analysis revealed a significant decrease of these cells … to potential polyclonal proliferation,
we analyzed the effects of … Rainbow mice 31,35,55 were employed for clonal analysis of …

… the yolk sac known as the blood island before the development … Blood was collected weekly
from recipient mice to determine … analysis revealed that purified LT-HSCs from either source (…

… inferred by retrospective clonal analyses in the mouse embryo, which revealed two clonally
distinct … To further substantiate that clones in both the yolk sac and heart derive from a single …